Ugandan officials are preparing to distribute a trial vaccine as part of efforts to contain an outbreak of Ebola in the capital, Kampala, a top health official said on Sunday.
A range of scientists are developing methodological frameworks relating to the planned deployment of more than 2,000 doses of a candidate vaccine against the Sudan strain of Ebola, said Pontiano Kaleebu, executive director of Uganda Virus Research Institute.
Procedure is being streamlined to get all the necessary regulatory approvals, he said. “This vaccine is not yet licensed.”
The World Health Organization said in a statement that its support to Uganda’s response to the outbreak includes access to 2,160 doses of trial vaccine.
“Research groups have been deployed to the field to work along with the surveillance teams as approvals are awaited,” the WHO statement said.
The candidate vaccine as well as candidate treatments are being made available through clinical trial protocols to further test for elegibility and safety, it said.
The vaccine maker wasn’t immediately known and there are no approved vaccines for the Sudan strain of Ebola that killed a nurse employed at Kampala’s main referral hospital.
A trial vaccine known as rVSV-ZEBOV, used to vaccinate 3,000 people at risk of infection during an outbreak of the Zaire strain of Ebola in eastern Congo between 2018 and 2020, proved effective in containing the spread of the plague there.
Uganda had multiple Ebola outbreaks, including one in 2000 that killed hundreds. The 2014-16 Ebola outbreak in West Africa killed more than 11,000 people, the disease’s largest death toll.
Tracing contacts is also key to stemming the spread of Ebola, which manifests as a viral hematologic fever.
At least 44 contacts of the victim in the current outbreak have been identified, including 30 health workers and patients, according to Uganda’s Ministry of Health.
Ebola is spread by contact with bodily fluids of an infected person or contaminated materials. Symptoms include fever, vomiting, diarrhea, muscle pain and at times internal and external bleeding.